Félix Carvalho Selected Research

Neoplasms (Cancer)

2/2024	Comparative In Vitro Study of the Cytotoxic Effects of Doxorubicin's Main Metabolites on Cardiac AC16 Cells Versus the Parent Drug.
12/2023	The role of inflammation and antioxidant defenses in the cardiotoxicity of doxorubicin in elderly CD-1 male mice.
10/2023	The Role of Nrf2 and Inflammation on the Dissimilar Cardiotoxicity of Doxorubicin in Two-Time Points: a Cardio-Oncology In Vivo Study Through Time.
8/2023	A Clinically Relevant Dosage of Mitoxantrone Disrupts the Glutathione and Lipid Metabolic Pathways of the CD-1 Mice Brain: A Metabolomics Study.
1/2023	Cannabinoid-mediated targeting of mitochondria on the modulation of mitochondrial function and dynamics.
1/2023	Cardiac Molecular Remodeling by Anticancer Drugs: Doxorubicin Affects More Metabolism While Mitoxantrone Impacts More Autophagy in Adult CD-1 Male Mice.
1/2022	Four decades of chemotherapy-induced cognitive dysfunction: comprehensive review of clinical, animal and in vitro studies, and insights of key initiating events.
1/2022	Chemobrain: mitoxantrone-induced oxidative stress, apoptotic and autophagic neuronal death in adult CD-1 mice.
11/2021	Role of Inflammation and Redox Status on Doxorubicin-Induced Cardiotoxicity in Infant and Adult CD-1 Male Mice.
5/2021	Inflammation as a Possible Trigger for Mitoxantrone-Induced Cardiotoxicity: An In Vivo Study in Adult and Infant Mice.

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Félix Carvalho Research Topics

Disease

22	Cardiotoxicity 02/2024 - 06/2002
22	Neoplasms (Cancer) 02/2024 - 02/2002
22	Hyperthermia 06/2020 - 04/2002
11	Inflammation (Inflammations) 12/2023 - 05/2013
11	Poisoning 01/2019 - 10/2006
9	Necrosis 11/2021 - 06/2010
8	Mitochondrial Diseases (Mitochondrial Disease) 01/2024 - 01/2013
7	Multiple Sclerosis 02/2024 - 05/2018
7	Hypertension (High Blood Pressure) 02/2021 - 02/2002
6	Pain (Aches) 01/2017 - 05/2013
5	Fibrosis (Cirrhosis) 12/2023 - 07/2009
4	Chemotherapy-Related Cognitive Impairment 08/2023 - 05/2018
3	Breast Neoplasms (Breast Cancer) 01/2023 - 04/2017
3	Renal Insufficiency (Renal Failure) 08/2022 - 12/2015
3	Gliosis 03/2021 - 01/2016
3	Body Weight (Weight, Body) 01/2021 - 04/2009
3	Weight Loss (Weight Reduction) 01/2020 - 09/2010
3	Parkinson Disease (Parkinson's Disease) 01/2016 - 01/2013
3	Heart Failure 06/2014 - 06/2009
3	Chromosomal Instability (Chromosome Stability) 06/2013 - 10/2011
3	Fanconi Anemia (Fanconi's Anemia) 06/2013 - 10/2011
2	Psoriasis (Pustulosis Palmaris et Plantaris) 02/2024 - 02/2014
2	Neuroblastoma 02/2024 - 01/2016
2	B-Cell Lymphoma (Lymphoma, B Cell) 10/2023 - 10/2015
2	Obesity 06/2023 - 01/2021
2	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2023 - 10/2014
2	Tachycardia (Tachyarrhythmias) 02/2021 - 01/2020
2	Acute Kidney Injury (Acute Renal Failure) 01/2020 - 11/2010
2	Attention Deficit Disorder with Hyperactivity (Attention Deficit Hyperactivity Disorder) 04/2018 - 08/2017
2	Thrombophlebitis 01/2017 - 04/2015
2	Gangrene 01/2017 - 04/2015
2	Infections 01/2017 - 01/2015
2	Jaundice (Icterus) 01/2015 - 08/2010
2	Gout 02/2014 - 02/2002
2	Hepatitis 08/2010 - 02/2002
2	Ischemia 06/2009 - 03/2009
2	Reperfusion Injury 03/2009 - 02/2002
2	Hyperplasia 07/2008 - 03/2005
1	Stroke (Strokes) 01/2024

Drug/Important Bio-Agent (IBA)

18	N-Methyl-3,4-methylenedioxyamphetamine (MDMA)IBA 01/2020 - 04/2002
10	Mitoxantrone (Novantrone)FDA LinkGeneric 08/2023 - 09/2013
9	Doxorubicin (Adriamycin)FDA LinkGeneric 02/2024 - 05/2018
9	ParaquatIBA 01/2024 - 10/2006
8	Proteins (Proteins, Gene)FDA Link 12/2023 - 11/2006
7	Ethanol (Ethyl Alcohol)IBA 01/2018 - 06/2008
7	CatecholaminesIBA 09/2013 - 06/2002
6	AntioxidantsIBA 12/2023 - 07/2008
4	Biomarkers (Surrogate Marker)IBA 11/2023 - 09/2013
4	Topoisomerase II InhibitorsIBA 10/2023 - 11/2021
4	CannabinoidsIBA 01/2023 - 01/2020
4	Cyclophosphamide (Cytoxan)FDA LinkGeneric 01/2022 - 09/2013
4	Synthetic CathinoneIBA 03/2021 - 08/2016
4	AmphetaminesIBA 01/2020 - 09/2013
4	AntidotesIBA 01/2019 - 07/2008
4	EnzymesIBA 01/2018 - 02/2002
4	Tramadol (K315)FDA LinkGeneric 01/2017 - 11/2013
4	Reactive Oxygen Species (Oxygen Radicals)IBA 06/2009 - 04/2002
4	Monoamine Oxidase (MAO)IBA 06/2009 - 08/2003
3	Antineoplastic Agents (Antineoplastics)IBA 02/2024 - 01/2022
3	Methylphenidate (Ritalin)FDA LinkGeneric 01/2024 - 08/2017
3	RNA Polymerase II (RNA Polymerase B)IBA 08/2022 - 12/2015
3	Adenosine Triphosphate (ATP)IBA 01/2020 - 05/2015
3	AmanitinsIBA 01/2019 - 06/2014
3	Cocaine (Cocaine HCl)IBA 01/2018 - 11/2010
3	1- Methyl- 4- phenyl- 1,2,3,6- tetrahydropyridine (MPTP)IBA 07/2017 - 01/2016
3	Tapentadol FDA Link 01/2017 - 01/2016
3	Opioid Analgesics (Opioids)IBA 01/2017 - 11/2013
3	diepoxybutaneIBA 06/2013 - 01/2006
3	HerbicidesIBA 04/2013 - 09/2009
3	Epinephrine (Adrenaline)FDA LinkGeneric 06/2009 - 08/2007
3	Purinergic P1 Receptors (Adenosine Receptor)IBA 07/2008 - 02/2004
3	1,3-dipropyl-8-(4-sulfophenyl)xanthine (PSPX)IBA 07/2008 - 02/2004
2	Amphetamine (Amfetamine)FDA LinkGeneric 01/2024 - 08/2003
2	thiazolyl blueIBA 01/2024 - 01/2020
2	Glutathione Peroxidase GPX1IBA 12/2023 - 10/2023
2	LipidsIBA 06/2023 - 07/2009
2	CytokinesIBA 01/2022 - 09/2014
2	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2021 - 06/2010
2	FlavonoidsIBA 01/2021 - 01/2018
2	Fluorouracil (Carac)FDA LinkGeneric 11/2019 - 10/2019
2	Glutamic Acid (Glutamate)FDA Link 10/2019 - 06/2009
2	XenobioticsIBA 04/2017 - 05/2011
2	CaspasesIBA 01/2017 - 10/2015
2	desomorphineIBA 01/2017 - 04/2015
2	Piperonyl Butoxide FDA Link 08/2016 - 01/2016
2	cypermethrin (alphamethrin)IBA 08/2016 - 01/2016
2	Member 1 Subfamily B ATP Binding Cassette TransporterIBA 05/2015 - 10/2006
2	Acetylcysteine (Siran)FDA LinkGeneric 02/2014 - 05/2012
2	Protective AgentsIBA 05/2012 - 10/2011
2	Glutathione (Reduced Glutathione)IBA 05/2012 - 08/2011
2	HepcidinsIBA 06/2010 - 06/2008
2	Nitric Oxide (Nitrogen Monoxide)FDA Link 06/2009 - 03/2005
2	Serotonin (5 Hydroxytryptamine)IBA 06/2009 - 08/2003
2	Mitochondrial DNA (mtDNA)IBA 01/2009 - 09/2007
1	Dimethyl FumarateIBA 02/2024
1	Neutral RedIBA 01/2024
1	Oxidopamine (6 Hydroxydopamine)IBA 01/2024

Therapy/Procedure

5	Therapeutics 10/2023 - 02/2014
4	Drug Therapy (Chemotherapy) 08/2023 - 05/2018
2	Surgical Amputation (Amputations) 01/2017 - 04/2015